Research Projects

Cell and developmental biology of Marine organisms

Funding Agency: Department of Biotechnology, Govt of India

Project Type: Multi Institutional

Period of Study: 02/09/2021 to 01/09/2024

Project Coordinator: Prof.I. S. Bright Singh

PI: Prof. Valsamma Joseph and Dr. Jayesh Puthumana

Co-I: Mr. Shibin S. P.

Project Cost: Rs. 301.23 lakhs

Collaborating Institutions: 1. C Abdul Hakeem College, Vellore
                                                              2. Bharathidasan University, Thiruchirapalli

Establishment of Functional Genomics and Metabolomics Platform for Augmented Production of Aquatic Bio-Resources and Discovery of Novel Molecules of Biomedical Importance.

Funding Agency: Higher Education Department, Govt. of Kerala

Period of Study: 16/02/2022 to 15/02/2024

Project Coordinator: Prof. Valsamma Joseph

PI: Dr. Sajeevan T. P., Dr.Jayesh Puthumana

Co-I: Mr. Shibin S. P. (Co-Investigator) 

Project Cost: Rs. 372.43 lakhs

Integrated genomic and metabolomic approach for the discovery of novel small molecules with anticancer activity from marine microorganisms R

Funding Agency: DBT, Govt.of India

Period of Study: 28/10/2021- 27/10/2024

PI: Dr. Sajeevan T. P.

Project Cost: Rs. 83.0416 lakhs

Microbiome of Glaciomarine system of Svalbard; diversity and its variability.

Funding Agency: Ministry of Earth Sciences

Period of Study: 05/07/2019 – 04/07/2022

Co-PI: Dr. Sajeevan T. P.

Project Cost: Rs. 40.843 lakhs

Establishment of Bioinformatics and Computational Biology Centre for Marine Bio-resource Conservation and Sustainable Utilization

Funding Agency: Department of Biotechnology, Govt. of India

Period of Study: 22/02/21-21/02/26

PI: Prof. Valsamma Joseph,  Dr.Sajeevan T. P., Prof.I.S. Bright Singh, Dr.Jayesh Puthumana, Mr. Shibin S. P.

Project Cost: Rs. 74.99 lakhs

Development of bioprocess for the production of a high-quality protein hydrolysate, edible calcium, and medical-grade collagen from NCAAH- RAS Fish post filleting.

Funding Agency: Seed Money Research Initiative- Cochin University of Science and Technology.

Period of Study: 22/07/2022 to 21/07/2024

PI: Mr. Shibin S. P.

Project Cost: Rs. 1.0 lakhs

 

Bioprospecting of Marine microbial diversity for various products under the Marine Bioresource and Biotechnology Network Programme

Funding Agency: Department of Biotechnology, Govt of India

Project Type: Single Institutional

Period of Study: 28/09/2021 to 27/09/2024

PI: Dr. Sajeevan T. P.

Project Cost: Rs. 83.0416 lakhs

 

 

Completed Projects

Bioprospecting for Neuroprotective compounds from an endosymbiotic fungi Aspergillus MCCF102 isolated form a marine sponge as potential drug candidates against neurodegenerative disorders

Funding Agency: Department of Biotechnology, Govt.of India

Period of Study: 22/02/2019- 21/02/2022

PI: Dr. Sajeevan TP

Project Cost: Rs. 53.886 lakhs

Bioprospecting for antitumor molecules from marine actinomycetes M

Funding Agency: University Grants Commission

Period of Study: 07-06-2012  – 06-06-2014

PI: Sajeevan TP

Project Cost: 3.83   lakhs

Bioactive peptides and Depsipeptides with potential anticancer activity from marine sponges and tunicates of Indian Ocean M

Funding Agency: Kerala State Council for Science, Technology and Environment
Period of Study: 16-09-2015 – 15-09-2018
PI: Sajeevan TP
Project Cost: 24.45 lakhs

Molecular screening, cell culture based isolation and characterization of finfish and shellfish viruses and establishment of National Repository

Funding Agency: Department of Biotechnology, Govt.of India

Project type: Multi-Institutional project

Period of study: 09/7/2017- 31/03/2021

Project Coordinator: Prof. I. S. Bright Singh

Principal Investigator: Dr. Sajeevan TP

Project Cost: 118.66 lakhs

Collaborators: 

  1. C. Abdul Hakeem College, Melvisharam, Vellore Dist., Tamil Nadu.
    Principal Investigator: Dr. A. S. Sahul Hameed
  2. Central Institute of Freshwater Aquaculture, Bhubaneswar, Odisha.
    Principal Investigator: Dr. Pramoda Kumar Sahoo
  3. Central Institute of Fisheries Education, Mumbai, Maharashtra.
    Principal Investigator: Dr. Rajendran K.V.
  4. Sher – E- Kashmir University of Agricultural Sciences Technology, Kashmir, Jammu & Kashmir
    Principal Investigator: Dr. Feroz A. Shah
Isolation and chemical characterisation of anticancer metabolites from marine actinomycetes and elucidation of mechanisms anticancer activity through Functional Signature Ontology (FUSION) mapping

Funding Agency: UGC, under Raman Fellowship for Post Doctoral Research in USA

Period of Study: 09-11-2016 – 31-09-2017

PI: Dr. Sajeevan TP  

Project Cost: USD 37200/+ Rs 50,000/-

Nutritional evaluation, segregation and production optimization of novel marine microalgae for establishment as live feeds in fish and shellfish culture

Funding Agency: DBT, Govt. of India

Period of Study: 20/6/2018-19/6/2021

Co-PI: Dr. Sajeevan TP

Project Cost: 70.912 lakhs

Marine synthetic biology: building national capacity and human resources

Funding Agency: Department of Biotechnology, Govt. of India

Period of Study: 28/12/2017 -27/12/2020

Co-PI: Dr. Sajeevan TP

Project Cost: 51.49 lakhs

Indo-US initiatives on innovative reforms in marine biotechnology education and research and development of sustainable aquaculture production systems for inclusive economic growth and sustainable development

Funding Agency: University Grants Commission, Govt. of India (under the Indo-US 21st Century Knowledge Initiative)
Period of Study: 01.08.2015-31-07-2018
Co-PI: Sajeevan TP
Project Cost: 125.29 lakhs

Development of an appropriate delivery system for dsRNA of CMG family hormone genes to effect maturation and spawning of Penaeus monodon under captivity

Funding Agency: KSCSTE Emeritus Scientist Scheme
Project Cost: Rs. 20, 82,000.0.

M1. Evaluating costs and benefits of prophylactic health products and novel alternatives on small holder aquaculture farmers in Asia and Africa (IMAQualate)

Funding Agency: Department of Biotechnology, Government of India,
Project Cost: Rs. 55.232.

Metabolite engineering in Penaeus monodon to accomplish maturation and spawning under captivity by way of RNA mediated silencing of CMG family hormones genes

Funding Agency:  UGC – BSR faculty Fellowship, University Grants Commission, New Delhi;
Period of Study: 2nd May 2015 to 1st May 2018
Project Cost: Rs. 25.74.

Selection and identification of immunocompetent early life stages of the giant fresh water prawn Macrobrachium rosenbergii based on differential mRNA expression.

Period of Study: 19-6-2013 to 18-6-2016
Funding Agency:Department of Science and Technology, Government of India
Project Cost:Rs. 43.67 lakhs

Detailed performance evaluation and accelerated commercialization of the nitrifying bioreactor technology in Indian market – Phase II.

Funding Agency: Department of Biotechnology, Government of India, Under SBIRI Scheme
Period of Study: 7-11-2013 to 7-11- 2016
Project Cost: Rs. 15.0 lakhs

Polyhydroxy butyrate from marine microorganisms for biomedical and aquaculture applications.

Funding Agency: Centre for Marine Living Resources and Ecology, Ministry of Earth Science, Government of India
Period of Study: 1-4-2012 to 31-3-2017
Project Cost: Rs.87.0 Lakhs.

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Immortalization of lymphoid cell culture from Penaeus monodon by transduction with oncogenes, ectopic expression of telomerase reverse transcriptase using shrimp specific expression vectors and hybridization with established cell lines.

Funding Agency: Department of Biotechnology, Government of India,
Period of Study:14-9-2012 to 13-9- 2015
Project Cost: Rs. 46. 07 Lakhs.

Development and optimization of vaccine to protect shrimp from white spot syndrome virus

Funding Agency: Department of Biotechnology, Government of India,
Period of Study: 24 -8-2009 to 31-3-2014
Project Cost: Rs. 57.03 Lakhs

Metagenomic approach to cloning and expression of endo and exo glucanase and β- 1,4 glucosidase from soil water system

Funding Agency: Department of Biotechnology, Government of India,
Period of Study: 28-9-2010 to 27-9-2014
Project Cost: Rs. 40.02 lakhs.

Optimization of the bioremediation technology developed for shrimp culture under closed system mode

Funding Agency: Ministry of Earth Science, Government of India,
Period of Study: October 2008 to October2011
Project Cost: Rs. 23.832 lakhs 

Development of anti-WSSV drugs from mangrove plants endemic to Indian coastal zone

Funding Agency: Department of Biotechnology, Government of India,
Period of Study: October 2006 –September 2009
Project Cost: Rs. 37.45 Lakhs.

Expression of virulence of Vibrio harveyi in Organic Recirculation Prawn Seed Production System (ORPSPS) and its management

Funding Agency: UGC,
Period of Study: July 2007-June 2010
Project Cost: Rs. 9.276 Lakhs.

Design modification and commercialization of nitrifying bioreactor technology for the establishment of organic recirculation prawn seed production system (Phase- I)

Funding Agency: Department of Biotechnology, Government of India,
Period of Study: September 2007-August 2010
Project Cost: Rs. 10.37 lakhs. 

Identification and removal of blocks on in vitro transformation and establishment of cell lines from Penaeus monodon

Funding Agency: Department of Biotechnology, Government of India,
Period of Study: October 2007- September 2010
Project Cost: Rs. 31.76 lakhs. 

Development and amplification of CMG family recombinant hormones, their antagonists and RNAi technique for induced maturation and spawning of Penaeus monodon

Funding Agency: Department of Biotechnology, Government of India,
Period of Study: 28-3-2005 to 31-12-2008
Project Cost: Rs. 38.69 lakhs. 

Programme support in marine biotechnology.

Funding Agency: Department of Biotechnology, Government of India,
Period of Study: April 2005- September 2008
Project Cost: Rs.139 lakhs.

Nitrifying bioreactors integrated into prawn hatchery systems: Biofilm structure, population dynamics, and kinetic modeling.

Funding Agency: Department of Science and Technology (DST), Govt. of India.
Period of Study: August 2006- March 2009
Project Cost: Rs. 13.9 lakhs.

Diseases of ornamental fishes: aetiology, disease management and development of biosecurity packages for exotic species.

Funding Agency: The Marine Products Export Development Authority (MPEDA), Ministry of Commerce, Government of India.
Period of Study: May 2007
Project Cost: Rs 8.59625 lakhs.

Development of an appropriate technology for bioremediation in shrimp grow out systems for disease management, productivity and aquaculture environment protection

Funding Agency: Indian Council of Agricultural Research (ICAR), New Delhi
Period of Study: 2003 October – 2006 October
Project Cost: Rs. 15,87,616.0.

Development of a comprehensive microbial technology for the protection of the larvae of Macrobrachium rosenbergii from vibriosis in hatchery. M

Funding Agency: Department of Science and Technology (DST), Govt. of India
Period of Study: November 2001 to November 2004
Project Cost: Rs. 15, 06, 651.00.

Development of cell culture systems from penaeid prawns for the isolation of White Spot Virus. M

Funding Agency: Department of Biotechnology, Govt. of India.
Period of Study: November 1999 to March 2003
Project Cost: Rs. 19, 94, 000.00.

Demonstration and validation of the nitrifying bioreactors developed for penaeid and non penaeid closed hatchery systems. M

Funding Agency: Department of Biotechnology, Govt. of India
Period of Study: July 2001 to March 2003
Project Cost: Rs. 3,93,400.00

Systemic Ectodermal Mesodermal Baculovirus Disease in Penaeids – Epizootiology, Immunodiagnostics and vaccine. M

Funding Agency: Indian Council of Agricultural Research
Period of Study: April 1998 to April 2002
Project Cost: Rs. 11, 75,576.00.

Screening of commercially available aquaculture medicine for the management of luminescent vibrios in penaeid hatchery systems M

Funding Agency: Marine Products Export Development Authority of India
Period of Study: June 2001 to Nov 2001
Project Cost: Rs. 2, 21, 951.0

Development of Disease Diagnosis and Management Strategies in Finfish and Shellfish Culture Systems.

Funding Agency: Department of Fisheries, Govt. of Kerala
Period of Study: August 1998 to July 2001
Project Cost: Rs.10,00,000.00.

Development of Microbial Technology for exclusion of vibrios from prawn larval rearing systems.
Development of primary cell cultures and cell lines from fresh water fishes to isolate viruses associated with EUS.

Funding Agency: State Committee on Science, Technology & Environment, Govt. of Kerala
Period of Study: January 1993 to January 1998
Project Cost: Rs. 2,17,150.00.

Development of bioreactors for nitrifying water in closed system prawn hatcheries.

Funding Agency: Department of Biotechnology, Govt. of India.
Period of Study: April 1995 to April 1998
Project Cost: Rs. 19,31,944.00

Coir Retting – Process upgradation and pollution abatement through Environmental Biotechnology.

Funding Agency: Coir Board
Period of Study: August 1993 to April 1998
Project Cost: Rs.5,99,200.0

Vibrionaceae associated with the larvae of Macrobrachium rosenbergii in hatchery – Systematics and pathogenicity.

Funding Agency: International Foundation for Science, Sweden
Period of Study: February 1990 to February 1995
Project Cost: US $ 9,600.00.

Vibrionaceae associated with the larvae of Penaeus indicus: Systematics and Pathogenicity.

Funding Agency: State Committee on Science, Technology & Environment. Govt. of Kerala. (Part of the Young Scientist award)
Period of Study: August 1990 to July 1992
Project Cost: Rs. 20,000.00.

Microorganisms associated with the eggs and larvae of Macrobrachium rosenbergii.

Funding Agency: Department of Science and Technology, Govt. of India, under the Young Scientist programme
Period of Study: January 1987 to July 1989
Project Cost: Rs. 98,000.0

Molecular screening, cell culture based isolation and characterization of finfish and shellfish viruses and establishment of National Repository

Funding Agency: Department of Biotechnology, Govt.of India

Project type: Multi-Institutional project

Period of study: 09/7/2017- 31/03/2021

Project Coordinator: Prof. I. S. Bright Singh

Principal Investigator: Dr. Sajeevan TP

Project Cost: 118.66 lakhs

Collaborators: 

  1. C. Abdul Hakeem College, Melvisharam, Vellore Dist., Tamil Nadu.
    Principal Investigator: Dr. A. S. Sahul Hameed
  2. Central Institute of Freshwater Aquaculture, Bhubaneswar, Odisha.
    Principal Investigator: Dr. Pramoda Kumar Sahoo
  3. Central Institute of Fisheries Education, Mumbai, Maharashtra.
    Principal Investigator: Dr. Rajendran K.V.
  4. Sher – E- Kashmir University of Agricultural Sciences Technology, Kashmir, Jammu & Kashmir
    Principal Investigator: Dr. Feroz A. Shah
Marine synthetic biology: building national capacity and human resource.

Funding Agency: Department of Biotechnology, Government of India,
Project type: Multi-Institutional
Period of Study:28-2-2017 to 27-2-2020
Project Cost: Rs. 51.49884.

Development and application of CMG family recombinant hormones, their antagonists and RNAi technique for induced maturation and spawning of Penaeus monodon.

Collaborators:  Central Institute of Brackishwater Aquaculture, Chennai
                                    Department of Zoology, Calicut University, Calicut.

Funding Agency: Department of Biotechnology, Govt. of India.

Period of Study: October 2005- September 2008,

Project Cost: Rs. 66.03 lakhs.

Development of appropriate bioremediation technology for zero-exchange creek-fed shrimp culture system.

Collaborator: M/s Pancham Aquaculture Limited, Mumbai.
Funding Agency: Department of Biotechnology, Govt. of India under the Institute-Industry Collaboration Programme.
Period of Study: September 2004 – September 2007
Project Cost: Rs. 19,38,000.00.

Detection, isolation and identification of anti-white spot syndrome virus molecules from selected species of marine biota and development of an anti-WSSV formulation.

Collaborator: National Centre for Cell Sciences, Pune.

Funding Agency: Department of Biotechnology, New Delhi.

Period of Study: 2003 September – 2005 September

Project Cost: Rs. 11, 65, 000.00.

Development and evaluation of small-scale solar treatment systems for contaminated drinking water.

Collaborator: University of Northumbria at Newcastle, U.K.
Funding Agency: The Wellcome Trust, UK.
Period of Study: November 2001 to June 2005,
Project Cost: UK Pounds 53,380.00.

Digitized inventory of marine bioresources with special reference to bacteria associated with marine plants and animals.

Collaborators: Multi-Institutional Consortium consisting of National Institute of Oceanography, Goa, Andhra University, Visakhapatnam, Annamalai University, Porto Novo and Cochin University of Science and Technology, Kochi.
Funding Agency: Department of Biotechnology and Department of Ocean Development, Govt. of India.
Period of Study: November 2001 to March 2003
Project Cost: Rs. 10,87,000.00.