Dr. Santhini Pulikkal Veettil

DBT-Ramalingaswami faculty fellow

Dr. Santhini Pulikkal Veettil received her B Sc (2006-2009) and M Sc (2009-2011) degree from Kannur University, kannur. She obtained her PhD degree in Chemical Sciences from  Academy of Scientific and Innovative Research (AcSIR), New Delhi and worked under the combined guidance of Dr. K V Radhakrishnan and Dr. R LuxmiVarma, Organic Chemistry Section, CSIR-NIIST, Thiruvananthapuram (April 2018). Soon after she was awarded the PDM Postdoctoral Fellowship-2018 to work with Prof. Wim Dehaen, Dept. of Chemistry, KU Leuven (University of Leuven), Belgium (2018-2021). In October 2021, she returned to India and joined as a Senior project associate with Dr. Sajeevan T. P , National Centre for Aquatic animal Health, CUSAT to work in a Department of Biotechnology sponsored research project entitled “Bio prospecting of Marine microbial diversity for various products under the Marine Bio resource and Biotechnology Network Programme” and after that, she was awarded National Postdoctoral Fellowship by DST-SERB to continue her research work with Dr. N Manoj, Dept. of Applied chemistry, CUSAT (February 2022-August 2022). Later, she was awarded the prestigious Ramalingaswami re-entry fellowship by the Department of Biotechnology, Govt. of India and in Sept 2022, she joined as DBT-Ramalingaswami faculty fellow to start her independent career at National Centre for Aquatic Animal Health, Cochin University of Science and Technology.  Her research focuses on1) isolation, characterization and total synthesis ofmarine natural products, especially isolated from unique marine environments for biomedical applications 2) medicinal and heterocyclic chemistry 3) Green and Sustainable organic synthesis.

Awards/Fellowships/Scholarships

  1. DBT-Ramalingaswami Re-entry Fellowship-2021
  2. SERB-National Postdoctoral Fellowship
  3. PDM-Postdoctoral fellowship– 2018 at KU Leuven, Belgium with Prof. WimDehaen,
  4. Junior Research Fellowship (JRF) and National Eligibility Test (NET), Council of Scientific and Industrial Research – 2011
  5. DST–Inspire–Junior Research Fellowship (JRF), DST, India– 2012 (not availed)
  6. Graduate Aptitude Test in Engineering (GATE score: 98%) – 2012
  7. 1st rank from Kannur University, M.Sc. Chemistry – 2011
  8. 1st rank from Kannur University, B.ScPolymer Chemistry – 2009

Academic Background

  • Ph. D. in Chemical Sciences (April 2018), research work carried out at CSIR–NIIST, Thiruvananthapuram,under the combined guidance of Dr. K. V. Radhakrishnan and Dr. R. Luxmi Varma, Degree awarded from Academy of Scientific and Innovative Research (AcSIR), New Delhi. Thesisentitled “Synthesis of Heterocycles and Carbocycles via Desymmetrization of Bicyclic Olefins and Multicomponent Reactions of Indoles”.
  • M. Sc. in Chemistry (2011), Kannur University, Kerala, India. First class with distinction (83%) and 1st rank.
  • B. Sc. in Chemistry specialized in Polymer Chemistry (Main) with physics and mathematics as subsidiary subjects (2009), Kannur University, Kerala, India. First class with distinction (92%) and 1st rank.

Professional Experience

  • September 2022-Present :    Ramalingaswami Faculty Fellow
  • February 2022-August 2022: National Postdoctoral Fellow-SERB, Dept. of Applied Chemistry, CUSAT
  • October 2021-February 2022: Research Associate at National Centre for Aquatic animal Health under Dr. Sajeevan T.P, CUSAT, Kochi.
  • 2018- 2021: PDM Postdoctoral fellow at University of Leuven (KU Leuven), Belgium. Research supervisor; Prof. Dr. Wim Dehaen.
  • 2012–2018: Research Fellow at Organic Chemistry Section of CSIR-NIIST, Trivandrum, India, under the supervision of Dr. K. V. Radhakrishnan, Dr. R. Luxmi Varma and Dr. Jubi John

 

Publications

  1. Ilkin, V.G., Beryozkina, T. V., Willocx, D., Silaichev, P.S., Veettil, S.P., Dehaen, W., Bakulev, V.A., 2022. Rhodium-Catalyzed Transannulation of 4,5-Fused 1-Sulfonyl-1,2,3-triazoles with Nitriles. The Selective Formation of 1-Sulfonyl-4,5-fused Imidazoles versus Secondary C–H Bond Migration. J. Org. Chem. 87, 12274–12286. view
  2. Omanakuttan, V.K., Santhini, P. V., Shaludheen, S., Varughese, S., Hopf, H., John, J., 2022. Tandem Reaction of 4‐Halo‐1,3‐Dicarbonyl Compounds with Alkynes towards 4‐Vinyl‐3(2 H )‐Furanones and 3(2 H )‐Furanone fused 2‐Pyridones. Asian J. Org. Chem. 11. view
  3. Pookkandam Parambil, S., Pulikkal Veettil, S., Dehaen, W., 2022. The Synthesis of Five-Membered N-Heterocycles by Cycloaddition of Nitroalkenes with (In)Organic Azides and Other 1,3-Dipoles. Synthesis (Stuttg). 54, 910–924. view
  4. Santhini, P.V., Das, G., Mole, J., Kumar, A.S., Vedhanarayanan, B., Praveen, V.K., John, J., 2022. An Efficient Magnesium Phyllosilicate‐Nano Palladium Hybrid Catalyst for the Selective Oxidation of Organosilanes. ChemistrySelect 7. view
  5. de Ridder, I., Kerkhofs, M., Veettil, S.P., Dehaen, W., Bultynck, G., 2021. Cancer cell death strategies by targeting Bcl-2’s BH4 domain. Biochim. Biophys. Acta – Mol. Cell Res. 1868, 118983. view
  6. Pulikkal Veettil, S., Pookkandam Parambil, S., Van Hoof, M., Dehaen, W., 2021. A Multicomponent Approach toward Angularly Fused/Linear Bitriazoles: A Cascade Cornforth Rearrangement and Triazolization. J. Org. Chem. 86, 4346–4354. view
  7. Van Hoof, M., Veettil, S.P., Dehaen, W., 2021. The Three-Component Synthesis of 4-Sulfonyl-1,2,3-triazoles via a Sequential Aerobic Copper-Catalyzed Sulfonylation and Dimroth Cyclization. Molecules 26. view
  8. Pookkandam Parambil, S., de Jong, F., Veys, K., Huang, J., Veettil, S.P., Verhaeghe, D., Van Meervelt, L., Escudero, D., Van der Auweraer, M., Dehaen, W., 2020. BOPAHY: a doubly chelated highly fluorescent pyrrole–acyl hydrazone –BF 2 chromophore. Chem. Commun. 56, 5791–5794. view
  9. Safarnejad Shad, M., Santhini, P.V., Dehaen, W., 2019. 1,2,3-Triazolium macrocycles in supramolecular chemistry. Beilstein J. Org. Chem. 15, 2142–2155. view
  10. Santhini, P. V., V., J., Pradhan, S.C., Lingamoorthy, S., P. R., N., M. V., C., Mishra, R.K., K. N., N.U., John, J., Soman, S., 2019. Indolo[3,2- b ]indole donor-based D–π–A dyes for DSCs: investigating the role of π-spacers towards recombination. New J. Chem. 43, 862–873. view
  11. Santhini, P. V., Smrithy, A.S., Irfana Jesin, C.P., Varughese, S., John, J., Radhakrishnan, K. V., 2018. Accessing highly functionalized cyclopentanoids via a cascade palladation approach: unprecedented benzylic C–H activation towards cyclopentenoindanes. Chem. Commun. 54, 2982–2985. view
  12. Santhini, P., Gopalan, G., Smrithy, A., Radhakrishnan, K., 2018. Rhodium(III)-Catalyzed C–H Activation/Alkylation of Diazabicyclic Olefins with Aryl Ketones: Facile Synthesis of Functionalized Cyclopentenes. Synlett 29, 2023–2026. view
  13. Santhini, P. V., Babu, S.A., Krishnan R, A., Suresh, E., John, J., 2017a. Heteroannulation of 3-Nitroindoles and 3-Nitrobenzo[ b ]thiophenes: A Multicomponent Approach toward Pyrrole-Fused Heterocycles. Org. Lett. 19, 2458–2461. view
  14. Santhini, P. V., Krishnan R, A., Babu, S.A., Simethy, B.S., Das, G., Praveen, V.K., Varughese, S., John, J., 2017b. One-Pot MCR-Oxidation Approach toward Indole-Fused Heteroacenes. J. Org. Chem. 82, 10537–10548. view
  15. Santhini, P. V., Nimisha, G., John, J., Suresh, E., Varma, R.L., Radhakrishnan, K. V., 2017c. Pd-Catalyzed oxidative annulation of enamides with diazabicyclic olefins: rapid access to cyclopentene fused 2-pyrrolines. Chem. Commun. 53, 1848–1851. view
  16. Santhini, P., Sarath Chand, S., John, J., Varma, R., Jaroschik, F., Radhakrishnan, K., 2017. Lewis Acid Catalyzed Three-Component [3+2] Cycloaddition Reaction Using Pentafulvene as 2π Component: An Easy Way to Construct Pentaleno(1,2-b)indoles. Synlett 28, 951–956. view
  17. Chand, S.S., Gopalan, G., Santhini, P. V., Preethanuj, P., John, J., Harakat, D., Jaroschik, F., Radhakrishnan, K. V., 2016. Lewis Acid Catalyzed Regioselective Hydroheteroarylation of Pentafulvenes. Org. Lett. 18, 964–967. view
  18. Chand, S.S., Saranya, S., Preethanuj, P., Dhanya, B.P., Jijy, E., Prakash, P., Sasidhar, B.S., Szymoniak, J., Santhini, P. V., Radhakrishnan, K. V., 2014. Trapping the Lewis acid generated transient species from pentafulvene derived diazanorbornenes with ortho-functionalized aryl iodides and aliphatic alcohols. Org. Biomol. Chem. 12, 3045–3061. view
  19. Prakash, P., Aparna, P., Jijy, E., Santhini, P., Varughese, S., Radhakrishnan, K., 2013. Rhodium(III)-Catalyzed C–H Activation of Phenylazoles toward C–N Bond Cleavage of Diazabicyclic Olefins: A Facile Access to Mono- and Biscyclo­pentenyl-Functionalized Aza-Heteroaromatics. Synlett 25, 275–279. view
  1. Presented a poster entitled “Heteroannulation of Indole: A Facile Multicomponent Approach Toward Pyrrolization and Indolization of Heterocycles’’ in the Merck Organic Chemistry Symposium(MOCS 2018) during 6-7 December, 2018 at Blankenberge, Belgium.
  2. Oral Presentation entitled “Pd-Catalyzed Oxidative Annulation of Enamides with Diazabicyclic Olefins: An Easy Access to Cyclopentene Fused 2- Pyrrolines”International Conference on “Tropical Plants and Molecular Design” held at T. K. M. Arts and Science College, Kollam  during February 14-15, 2017.
  3. Presented a poster entitled “Rhodium Catalyzed Oxidative Coupling of Salicylaldehyde with Diazabicyclic Olefins: a One Pot Strategy towards the Synthesis of Fused Ring Chromanones” in the 6th International Symposium on “Current Trends in Drug Discovery Research” (CTDDR-2016) held at CDRI, Lucknow during 25th-28th February 2016.
  4. Oral Presentation entitled “Pd-Catalyzed Oxidative Annulation of Enamides with Diazabicyclic Olefins: A Rapid Access to Cyclopentene Fused 2-Pyrrolines”53 rd Annual Convension of Chemists 2016 held at GITAM University Visakhapatnam during December 27-29, 2016.
  1. Presented a poster entitled “Palladium/Lewis Acid Mediated Reaction of Pentafulvene Derived Diazabicyclic Olefins: Efficient Access to Polyheterocycles”International Conference on “Nascent Developments in Chemical Sciences: Opportunities for Academia-Industry Collaboration (NDCS-2015)” held at BITS Pilani, Pilani during October 16-18, 2015.
  2. Presented a poster entitled “Palladium/Lewis Acid Catalyzed Reaction of Pentafulvene Derived Diazabicyclic Olefins: Efficient Access to Polyheterocycles”National Conference on entitled “Transcending Frontiers in Organic Chemistry (TFOC-2014)”during October 09-11, 2014 held at CSIR-NIIST, Trivandrum.