Bioprospection refers to the process by which biomolecules are identified and isolated from living organisms like bacteria, fungi, plants, invertebrates etc. Compounds thus isolated are termed as natural products and they have proven to be excellent source of compounds with therapeutic as well as non-therapeutic purposes. Continued focus on terrestrial sources led to the rediscovery of already described molecules as a result of which researchers have shifted their attention towards under-explored habitats. These include the marine environment, polar regions, deserts and other regions characterised by extreme weather conditions. With its excellent biodiversity the marine environment has been described as a treasure trove of natural products. Several marine taxa, like bacteria (including cyanobacteria), fungi, certain algae, sponges, soft corals and gorgonians, sea hares and nudibranchs, bryozoans and tunicates are demonstrably rich sources of pharmacologically active natural products. With the emergence of antibiotic-resistant pathogens, new pathogens and diseases for which drugs are not yet available marine natural product research has a key role to play in the control and combat of diseases.

Recent Updates

  • Santhini P.V awarded the prestigious “Ramalingaswami Re-entry Fellowship”  instituted by The Department of Biotechnology, Ministry of Science and Technology, Government of India.
  • Roseitranquillus sediminis nov., sp. nov. a novel genus and species of the family Rhodobacteraceae, isolated from sediment of an Arctic fjord by M.D Umar, Ph D scholar under the guidance of Dr. Sajeevan T. P.

Work Elements

  • Isolation of Actinomycetes, Bacteria and Fungi from various environmental samples-Actinomycete and bacteria isolated from marine sediments, mangrove sediments, polar regions and marine invertebrates (sponges & ascidians) form the base of natural product research carried out at the centre. Around 300 isolates of these microbes are stored in the culture collection of the centre. A novel genus namely Roseitranquilis have been recently discovered from polar sediments.
  • Anti-cancer compounds: Potential anti-cancer compounds (Ikarugamycin like polyketide and 1-Acetyl B-Carboline) were isolated from Actinomycete strains isolated from Arabian sea sediments.
  • Anti-inflammatory/Neuroprotective compounds: Two new dipyrrolobenzoquinone derivatives Terreusinone B and C, along with a known analogue Terreusinone have been isolated from the marine sponge derived fungus Aspergillus sp. MCCF 102.
  • Anti-bacterial compounds: All microbial isolates obtained during the studies are routinely screened for their anti-bacterial properties through various assays.
  • Genomic-driven natural product discovery: Whole genome sequence of isolated microbes can reveal the biosynthetic gene clusters present in them which can provide a better understanding of pathways involved in natural product synthesis. In addition, silent gene clusters could be identified and targeted for inducing the production of their respective compounds.
  • Nanoparticles as drug delivery system: The efficacy of chitosan nanoparticles as drug delivery system has been tested on human cancer cell lines.
  • Biomaterials : Production of Polyhydroxyalkanoate Bioplastics, and various applications of these bioplastics.

Research Projects

  • Establishment of Functional Genomics and Metabolomics Platform for Augmented Production of Aquatic Bio-Resources and Discovery of Novel Molecules of Biomedical Importance. funded by Higher Education Department, Govt. of Kerala
  • Integrated genomic and metabolomic approach for the discovery of novel small molecules with anticancer activity from marine microorganisms  funded by Department of Biotechnology, Govt of India
  • Microbiome of Glaciomarine system of Svalbard; diversity and its variability funded by Ministry of Earth Sciences
  • Bioprospecting of Marine microbial diversity for various products under the Marine Bioresource and Biotechnology Network Programme funded by Department of Biotechnology, Govt of India
  • Bioprospecting for Neuroprotective compounds from an endosymbiotic fungi Aspergillus MCCF102 isolated form a marine sponge as potential drug candidates against neurodegenerative disorders  funded by Department of Biotechnology, Govt.of India
  • Bioprospecting for antitumor molecules from marine actinomycetes funded by University Grants Commission, Govt.of India
  • Bioactive peptides and Depsipeptides with potential anticancer activity from marine sponges and tunicates of Indian Ocean funded by Kerala State Council for Science, Technology and Environment 
  • Isolation and chemical characterisation of anticancer metabolites from marine actinomycetes and elucidation of mechanisms anticancer activity through Functional Signature Ontology (FUSION) mapping funded by UGC (Raman PDF)
  • Indo-US initiatives on innovative reforms in marine biotechnology education and research and development of sustainable aquaculture production systems for inclusive economic growth and sustainable development funded by University Grants Commission, Govt. of India (under the Indo-US 21st Century Knowledge Initiative)

Research Publications

  1. Deepa, G, AnoopB.S, Krishnapriya R.S. Dhaneesha M, S, Sajeevan T.P. (2022) Folate functionalized chitosan nanoparticles as targeted delivery systems for improved anticancer efficiency of cytarabine in MCF-7 human breast cancer cell lines. International Journal of Biological Macromolecules 199150–161 view
  2. Niveditha, Lekshmi, Peng Fu, Tiago F. Leao, Te Li, Tingting Wang, Remington X. Poulin, Lorena Rigo Gaspar, C. Benjamin Naman, and Sajeevan Thavarool Puthiyedathu. (2022) Targeted isolation of two new anti-inflammatory and UV-A protective dipyrroloquinones from the sponge-associated fungus Aspergillus tamarii MCCF102.” Planta MedicaAAM 88(09/10): 774-782. view
  3. Umar, Md, Kottekkatu Padinchati Krishnan, Rupesh Kumar Sinha, Thasreefa Kannukkarathi, Titus Susan Merlin, Jeslin Illiparambil Johnson, Valsamma Joseph, and Sajeevan Thavarool Puthiyedathu. (2021) Roseitranquillus sediminis gen. nov., sp. nov. a novel genus and species of the family Rhodobacteraceae, isolated from sediment of an Arctic fjord. Antonie van Leeuwenhoek114, no. 12: 2147-2162. view
  4. Dhaneesha, Mohandas, Md Umar, Titus Susan Merlin, Kottekkatu Padinchati Krishnan, Vrinda Sukumaran, Rupesh Kumar Sinha, Abdulaziz Anas, Peng Fu, John Bryan MacMillan, and Thavarool Puthiyedathu Sajeevan. (2021) Pseudonocardia cytotoxica sp. nov., a novel actinomycete isolated from an Arctic fjord with potential to produce cytotoxic compound. Antonie Van Leeuwenhoek114, no. 1 : 23-35. view
  5. Krishnankutty Chandrika, Sivakumar, and Sajeevan Thavarool Puthiyedathu. (2021) Challenges and prospects of Viral Envelope protein VP28‐based control strategies to combat white spot syndrome virus in penaeid shrimps: a review. Reviews in Aquaculture 13, no. 1: 734-743. view
  6. Mohandas, S.P., Balan, L., Gopi, J., Anoop, B.S., Mohan P, S., Philip, R., Cubelio, S.S., Singh, I.S.B., 2021. Biocompatibility of polyhydroxybutyrate-co-hydroxyvalerate films generated from Bacillus cereus MCCB 281 for medical applications. Int. J. Biol. Macromol. 176, 244–252. doi:10.1016/j.ijbiomac.2021.02.006 view
  7. Leber, C.A., Naman, C.B., Keller, L., Almaliti, J., Caro-Diaz, E.J., Glukhov, E., Joseph, V., Sajeevan, T.P., Reyes, A.J., Biggs, J.S. and Li, T., (2020). Applying a chemogeographic strategy for natural product discovery from the marine cyanobacterium Moorena bouilloniiMarine drugs18(10), p.515. view
  8. Sivakumar, Krishnankutty Chandrika, Jin Haixiao, C. Benjamin Naman, and P. Sajeevan. (2020) Prospects of multitarget drug designing strategies by linking molecular docking and molecular dynamics to explore the protein–ligand recognition process. Drug Development Research 81, no. 6 : 685-699. view
  9. Sajeevan, T. P. (2020) Endophytic fungi isolated from the marine sponges as a source of potential bioactive compounds. Journal of Aquatic Biology & Fisheries 8 : 58-66. view
  10. Li, Te, Ning Wang, Ting Zhang, Bin Zhang, Thavarool P. Sajeevan, Valsamma Joseph, Lorene Armstrong, Shan He, Xiaojun Yan, and C. Benjamin Naman. (2019) A systematic review of recently reported marine derived natural product kinase inhibitors. Marine drugs 17, no. 9 : 493. view
  11. Dhaneesha, M., O. Hasin, K. C. Sivakumar, R. Ravinesh, C. Benjamin Naman, S. Carmeli, and P. Sajeevan. (2019) DNA Binding and Molecular Dynamic Studies of Polycyclic Tetramate Macrolactams (PTM) with Potential Anticancer Activity Isolated from a Sponge-Associated Streptomyces zhaozhouensis subsp. mycale subsp. nov. Marine Biotechnology 21, no. 1 (2019): 124-137. view
  12. Deepa, G., K. C. Sivakumar, and P. Sajeevan. (2018) Molecular simulation and in vitro evaluation of chitosan nanoparticles as drug delivery systems for the controlled release of anticancer drug cytarabine against solid tumours. 3 Biotech 8, no. 12 : 1-11. view
  13. Mohandas, S.P., Balan, L., Jayanath, G., Anoop, B.S., Philip, R., Cubelio, S.S., Bright Singh, I.S., 2018. Biosynthesis and characterization of polyhydroxyalkanoate from marine Bacillus cereus MCCB 281 utilizing glycerol as carbon source. Int. J. Biol. Macromol. 119, 380–392. doi:10.1016/j.ijbiomac.2018.07.044 view
  14. Dhaneesha, M., C. Benjamin Naman, K. P. Krishnan, Rupesh Kumar Sinha, P. Jayesh, Valsamma Joseph, I. S. Bright Singh, William H. Gerwick, and P. Sajeevan. (2017) Streptomyces artemisiae MCCB 248 isolated from Arctic fjord sediments has unique PKS and NRPS biosynthetic genes and produces potential new anticancer natural products. 3 Biotech 7, no. 1 : 1-10. view
  15. Mohandas, S.P., Balan, L., Lekshmi, N., Cubelio, S.S., Philip, R., Bright Singh, I.S., 2017. Production and characterization of polyhydroxybutyrate from Vibrio harveyi MCCB 284 utilizing glycerol as carbon source. J. Appl. Microbiol. 122, 698–707. doi: 10.1111/jam.13359 view
  16. Sivakumar, K. C., P. Sajeevan, and IS Bright Singh. (2016) Marine derived compounds as binders of the White spot syndrome virus VP28 envelope protein: In silico insights from molecular dynamics and binding free energy calculations. Computational Biology and Chemistry 64: 359-367. view
  17. Dhaneesha M, Sajeevan T.P,P.Krishnan, Bright Singh I.S (2015). Apoptosis Mediated Anticancer Activity of Streptomyces sp. MCCB 248 Isolated from an Arctic Fjord, Kongsfjorden, Svalbard, on NCI-H460 Human Lung Cancer Cell Line. Marine Drugs. 13(12) 7171. view
  • Balan, L., Mohandas, S.P., Priyaja, P., Philip, R., Bright Singh, I.S., 2020. Polyhydroxyalkanoate Producing Bacteria from North Eastern Arabian Sea (NEAS), in: Joshi, K.K., Varghese, M., Kaladharan, P., Sreenath, K.R., S., L., Sanil, N.K., Hatha, A.A.M., Shinoj, P., Padua, S., Gills, R., Jayakumar, C. V. (Eds.), Marine Ecosystem Challenges & Opportunities (MECOS 3). Marine Biological Association of India, Kochi, Kerala, India, p. 421. view
  • Mohandas, S.P., Balan, L., Bhaskaran, A., Philip, R., Bright Singh, I.S., 2016. Production and characterization of PHA from Bacillus cereus MCCB 281 and its biomedical application-A preliminary study, in: 4th International Conference on Nanomedicine and Tissue Engineering (ICNT2016).
  • Mohandas, S.P., Balan, L., Lekshmi, N., Cubelio, S.S., Philip, R., Bright Singh, I.S., 2015. Production and characterization of polyhydroxybutyrate from bioluminescent Vibrio harveyi MCCB284 isolated from Phallusia nigra, in: International Conference on New Horizons in Biotechnology (NHBT-2015). Thiruvananthapuram, Kerala, India, p. 164.
  • Balan, L., Mohandas, S.P., Philip, R., Bright Singh, I.S., 2014. Screening and Isolation of Polyhydroxyalkanoate Producing Bacteria from Goa Coast, in: MECOS2 Marine Ecosystems Challenges and Oppurtunities- International Symposium. Marine Biological Association of India, Kochi, pp. 274–275. view
  1. Dhaneesha M (2018) [Reg. No.: 4404] Marine Isolates Streptomyces sp. MCCB 267 and Pseudonocardia sp. MCCB 268 as source of Potential Anticancer Molecules Ikarugamycin Type Polyketides and 1-Acetyl-β-Carboline: Isolation, Purification and in vitro Evaluation of Anticancer Activity view view
  2. Susan Joy (2019) [Reg. No.:4185)] Biochemical effects of thermal stress in a tropical teleost fish Etroplus suratensis (Bloch, 1790) view view
  3. Sowmya P Mohandas 2020 Development of nanoparticles and films of polyhydroxyalkanoates from marine bacteria view view
  4. Sivakumar K.C. (2021) [Reg. No. 4847] Structure based in silico screening for antiviral lead compounds from marine sources against White Spot Syndrome Virus: A multi-target drug discovery approach view view
  5. Lekshmi N. (2021) [Reg. No.: 4661] Sponge associated fungus Aspergillus tamarii MCCF 102 is a potential source of the anti-inflammatory dipyrrolobenzoquinones Terreusinone and Terreusinone B for neuroprotective drug development

Thrust Areas

  • Isolation of Actinomycetes, Bacteria and Fungi from various environmental samples
  • Anti-cancer compounds
  • Anti-inflammatory / Neuroprotective compounds
  • Anti-bacterial compounds
  • Genomic-driven natural product discovery
  • Nanoparticles as drug delivery system
Collaborating Institutes
Scripps Institution of Oceanography

Our Team

Dr.Sajeevan T.P. Associate Professor NCAAH CUSAT

Dr. Sajeevan T. P.

Dr. Dhaneesha M.

Dr. Santhini P. V.

Dr. Jisha Kumaran

Deepa G Ncaah

Deepa G.

Merlin T. S.

Krishna Priya R. S.

Rojin Joseph

Salini S

Linu Balan

Jini Jimmy